Werner Research Group

Synthetic Organic & Medicinal Chemistry

Research Overview:


We are interested in the discovery of new chemical reactions, the synthesis of interesting organic products, and the application of our products to catalysis, chemical biology, and medicine.

Publications:
  • Rau, H. H.*; Werner, N. S. "Stereocontrolled Synthesis of (E)-Stilbene Derivatives by Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction" Bioorganic Med. Chem. Lett. 2018, 28, 2693–2696.
  • Maedgen, R. L.*; Pereira, M. R.*; Werner, N. S. “Diastereoselectivity of the Nucleophilic Addition Reaction of the (±)-Menthylmagnesium Chloride Grignard Reagent with Phenyl Isocyanate” J. Utah Acad. Sci. Arts Lett. 2017, 94, 327–334.
    • Awarded the Best Physical Science Paper in the The Journal of the Utah Academy 2017–2018.
  • Butterfield, A. G.*; Prater, M. P.*; Werner, N. S. “Preparation of t-Butyldimethylphosphine Borane and t-Butyldiethylphosphine Borane by Selective Grignard Reagent Substitution of Phosphorus Trichloride” A. J. U. R. 2016, 13, 51–57.
  • Chang, W.-T.; Smith, R. C.; Regens, C. S.; Bailey, A. D.; Werner, N. S.; Denmark, S. E. “Cross-Coupling with Organosilicon Compounds” Org. React. 2011, 75, 213–746.
  • Denmark, S. E. and Werner, N. S. “gamma-Selective Cross-Coupling of Allylic Silanolate Salts with Aromatic Bromides Using Trialkylphosphonium Tetrafluoroborate Salts Prepared Directly from Phosphine•Borane Adducts” Org. Lett. 2011, 13, 4596–4599.
    • Highlighted in Synfacts 2011, 11, 1230–1230.
  • Denmark, S. E. and Werner, N. S. “On the Stereochemical Course of Palladium-Catalyzed Cross-Coupling of Allylic Silanolate Salts with Aromatic Bromides” J. Am. Chem. Soc. 2010, 132, 3612–3620.
  • Denmark, S. E. and Werner, N. S. “Cross-Coupling of Aromatic Bromides with Allylic Silanolate Salts” J. Am. Chem. Soc. 2008, 130, 16382–16393.
  • Checked “Synthesis of 2-Substituted Biaryls via Cu/Pd-Catalyzed Decarboxylative Cross-Coupling of 2-Substituted Potassium Benzoates: 4-Methyl-2’-Nitrobiphenyl and 2-Acetyl-4’-Methylbiphenyl” Org. Synth. 2008, 85, 196–208.

*denotes an undergraduate student coauthor.

National & Regional Presentations:
  • Rau, H. H.*; Werner, N. S. 258th American Chemical Society National Meeting & Exposition. San Diego, CA. August 28th, 2019. (poster)
  • Ruesch, G. L.*; Rowley, S. L.*; Mifflin, M. C.*; Werner, N. S. 258th American Chemical Society National Meeting & Exposition. San Diego, CA. August 26th, 2019. (poster).
  • Marcus M. C.*; Werner, N. S. Utah Academy of Sciences, Arts & Letters Annual Conference. Ogden, UT. March 23rd, 2019. (poster)
  • Ruesch, G. L.*; Werner, N. S. Utah Academy of Sciences, Arts & Letters Annual Conference. Ogden, UT. March 23rd, 2019. (poster)
  • Smith M. B.*; Werner, N. S. 12th Utah Conference on Undergraduate Research. Cedar City, UT. February 9th, 2018. (poster)
  • Pereira, M. R.*; Maedgen, R. L.*, Werner, N. S. Utah Academy of Sciences, Arts & Letters Annual Conference. Orem, UT. April 7th, 2017.
  • Clark, K. J.*; Werner, N. S. 253rd American Chemical Society National Meeting & Exposition. San Francisco, CA. April 3rd, 2017. (poster)
  • Holt, H.*; Werner, N. S. 251st American Chemical Society National Meeting & Exposition. San Diego, CA. March 14th, 2016. (poster)
  • Maedgen, R. L.*; Tomlinson, K. A.*; Werner, N. S. 251st American Chemical Society National Meeting & Exposition. San Diego, CA. March 14th, 2016. (poster)
  • Butterfield, A. G.*; Werner, N. S. 251st American Chemical Society National Meeting & Exposition. San Diego, CA. March 16th, 2016. (poster)
  • Maedgen, R. L.*; Werner, N. S. 10th Utah Conference on Undergraduate Research. Salt Lake City, UT. February 19th, 2016.
*denotes an undergraduate student coauthor.

Current and Former Research Students:

Luke Shaner, B.S. 2020 (expected)
Madison Fisher, B.S. 2021 (expected)
Trace Wilson, B.S. 2020 (expected)
Sydney Rowley, B.S. 2021 (expected)
Jordan Terry, B.S. 2021 (expected)
Barry Kreyling, B.S. 2020 (expected)
Emily Bryan Olsen, B.S. 2019 (Nutrition Major, Chemistry Minor)
Zach Rogers, B.S. 2019 (Chemistry Ph.D. program, The Ohio State University)
Garett Ruesch, B.S. 2020 (expected)
Marcus Mifflin, B.S. 2019 (Chemistry Ph.D. program, The University of Utah)
J. Brenton Bushnell, B.S. 2020 (expected)
Hayden Bishop, B.S. 2020 (expected)
Mason Smith, B.S. 2019 (Nutrition Major, Chemistry Minor)
Chris Ozeretny, B.S. 2020 (expected)
Chris Christiansen, B.S. 2018 (Emergency room scribe, Dixie Regional Medical Center)
Haley Shumway, B.S. 2017 (D.O. program, Rocky Vista University - Ivins)
Kyle Clark, B.S. 2018 (Chemistry Ph.D. program, Brigham Young University)
Adam Eddington, B.S. 2017 (M.D. program, Dartmouth College)
Richie Sauceda, B.S. 2017 (J.D. program, University of Minnesota)
Peter Kemp, B.S. 2017 (D.P.M. program, Kent State University)
Samantha Bengtzen, B.S. 2017 (M.D. program, The University of Utah)
Myla Pereira, B.S. 2018 (D.O. program, Nova Southeastern University)
Krysten Tomlinson, B.S. 2018 (Music Major, Chemistry Minor)
Taylor Sorenson, B.S. 2016 (D.O. program, Pacific Northwest University)
Travis Tuttle, B.S. 2016 (D.D.S. program, The University of Iowa)
Brandon Wilburn, B.S. 2016 (D.M.D. program, Oregon Health & Sciences University)
E.J. Leavitt, B.S. 2017 (D.O. program, Rocky Vista University)
Rebecca Maedgen, B.S. 2016 (Chemistry Ph.D. program, University of Pittsburgh)
Karina Jonas Ballard, B.S. 2016 (Finance Major, Chemistry Minor)
Hailee Holt Rau, B.S. 2017 (Chemistry Ph.D. program, The University of Oklahoma)
Auston Butterfield, B.S. 2015 (Chemistry Ph.D. program, Pennsylvania State University)
Matthew Prater, B.S. 2015 (Chemistry Ph.D. program, The University of Utah)
Stephan Maman, B.S. 2015 (M.D. program, Pennsylvania State University)

Research Group Pictures:

Summer 2019
(from left Sydney Rowley, Trace Wilson, Luke Shaner, Garett Ruesch, Madison Fisher, Nathan Werner)

Summer 2018
(from left Hayden Bishop, J. Brenton Bushnell, Marcus Mifflin, Garett Ruesch, Nathan Werner)

Summer 2017
(from left J. Brenton Bushnell, Marcus Mifflin, Chris Ozeretny, Mason Smith, Nathan Werner)

Summer 2016
(from left Samantha Bengtzen, E.J. Leavitt, Adam Eddington, Haley Shumway, Kyle Clark, Chris Christiansen, Nathan Werner)

Summer 2015
(from left Krysten Tomlinson, Richie Sauceda, Hailee Holt, Brandon Wilburn, E.J. Leavitt, Nathan Werner)

Summer 2014
(from left Rebecca Maedgen, Matt Prater, EJ Leavitt, Nathan Werner)

Summer 2013
(from left Matt Prater, Hailee Holt, Karina Jonas, Marianna Katz, Auston Butterfield, Nathan Werner)